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A. Two extremely compact hollow cylinders, which come in a variety of widths and lengths, are implanted within the penis. A small container that holds fluid for the cylinders is inserted in the lower part of the abdomen and a pump is implanted in the scrotum. The patient squeezes the pump several times, which transfers the fluid from the container to the inflatable cylinders, which then expand, widening and lengthening the penis. To get rid of the erection, the valve at the top of the pump is squeezed and the fluid returns to the abdominal reservoir, causing penile flaccidity.
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Whether the cause of impotence is physiological or psychological, both the patient and his partner often experience a range of intense feelings and emotions. Any of these feelings can lead to a sense of hopelessness and lower self-esteem.
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To extend this finding to other models, the experiment was repeated using the 4T1 mammary carcinoma genetically modified to express the influenza-derived HA as a model tumor antigen (Fig. 3 B). Mice were challenged on day 0 with 0.5 x 106 4T1-HA cells. On the next day they received 3 x 106 HA-specific naive CD8+ T cells. After adoptive transfer, the mice were either treated with sildenafil or left untreated. As with the C26GM experiments, no therapeutic benefit was observed with ACT alone, whereas sildenafil + ACT imparted the greatest antitumor benefit. Sildenafil treatment alone, instead, substantially delayed tumor progression in immunocompetent BALB/c mice but not in immune-deficient Rag-2�/� mice (Fig. S3, available at http://www.jem.org/cgi/content/full/jem.20061104/DC1). These data confirm the immunomodulatory properties of PDE5 inhibitors in augmenting the therapeutic efficacy of ACT and demonstrate a role of sildenafil in modifying the tumor microenvironment rendering it more susceptible to CTL-mediated cytotoxicity.
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"It's relatively common in men with diabetes and various forms of vascular disease, or men who've previously had infections -- usually infections of a penile prosthesis," Sharlip said. "There are men who have such severe fibrosis that nothing can be done to restore their natural erection function, other than to implant a surgical prosthesis," he added.
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A. Many men and their partners don't like the device because the erection it produces is not "normal." Some pump users complain that their penis feels numb, or that it becomes discolored, misshapen, and cold to the touch. Many couples complain about the interruption of intimacy it brings to lovemaking. Also, some men complain that the constriction ring at the base of the penis causes mild discomfort upon ejaculation or varying degrees of ejaculation impairment.
In the 1930s the American radio airwaves were bombarded with such advertising, first from domestic stations and then upon action by the American Medical Association the media blitz was shifted to superpower Mexican border-blasters.
Physical causes of ED are related to a breakdown or damage to the sequence of events that lead to an erection. This sequence involves nerve impulses in the brain, spine, and penis as well as the subsequent response in the muscles, fibrous tissues, veins and arteries in and near the corpora cavernosa.
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A recent study of more than 8,000 Australian men between the ages of 16 and 59 found that those who smoked less than a pack a day had a 24 percent increased risk of erectile problems. And, as the number of cigarettes smoked went up, so, too, did the chances of erectile dysfunction. Those men who averaged more than 20 cigarettes a day increased their risk of erectile dysfunction by 39 percent, reported the study, published in the journal Tobacco Control.
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